The museum ticket office has been built in a pharmacy dating back to the beginning of the nineteenth century.

The collection housed inside the seventeenth century  Palazzo Santi boasts a series of precious polychrome terracotta vases (11th-16th centuries) and an extraordinary nucleus of sculptures, which includes works of wood, terracotta, stuccoes and stone dating back to between the 13th and 15th centuries, rare examples of the mediaeval heritage of sacred art. Of particular importance is the Madonna di Poggioprimocaso, a monumental example of the flourishing local production of wooden polychrome Madonna statues. The statue of Tobias and the Angel exhibited in the chancel of the Church of Sant’Antonio Abate completes the collection.

From the 13th century onwards, Umbrian churches were enriched with sculptures created directly or influenced by sculptors from northern Europe. In the following centuries, Umbrian sculpture followed the methods of sculpture from Abruzzo, the main features of which were the accentuated archaic expression, the frontal view of the image and the expressiveness of the faces. These elements are widely found in the sculptures of Cascia.

One section of the museum preserves paintings by Lazzaro Baldi and Domenico Corvi; a tiny room is dedicated to the patron, Cardinal Fausto Poli, who came from the area and was the powerful secretary of Pope Urban VIII. The Palazzo also houses a collection of archaeological material, the most striking of which comes from Villa San Silvestro, home to an important temple and village, and the funerary accoutrements of the Hellenist tomb (3rd-2nd century BC) discovered in nearby Maltignano.